Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Bw16 exhibits additive inheritance.
Candidate Genes
A search for candidate genes was performed using DU6 and DU6i high body weight selection lines and lean unselected lines DUKs and DBA/2. RNA from epididymal fat tissue of 20 males from each line (DU6, DU6i, DUKs and DBA2/J) was pooled for analysis in Affymetrix GeneChips and resulted in the identification of 77 differentially expressed candidate genes. Of these, 14 genes are located in QTLs intervals affecting body weight and abdominal fat weight. Mapping and Phenotype information for this QTL, its variants and associated markersJ:66233QTL effecting body weight, obesity and muscle weight were found on mouse Chromosomes 1, 4, 5, 7, 11, 12, 13, and 17 and for leptin on 14 and insulin on chromosome 4. The cross used in the genome wide scan included approximately 400 F2 mice from a (DU6i xDBA/2)F1 intercross. DU6i is a strain selected for high body weight. 93 microsatellite markers were analyzed in the genome wide scan. Locations of the QTLs were provided by the authors and may not be equivalent to the closest microsatellites. Abdominalfat percent QTL 5, molecular weight of quadriceps QTL 2, abdominal fat weight QTL 5, body weight QTL 16, spleen weight QTL 1, body weight QTL 4 and molecular weight of quadriceps QTL 3 were mapped to mouse Chromosome 11 to cM positions 9, 10, 12, 14, 39,55, and 59 respectively.10.03.2014 - Curator Note: We had originally associated the abdominal fat weight QTL 5 identified here, mapping to 12cM on mouse Chr 11, as Afw5. Afw5 was originally mapped using a different cross, an outbred cross of DU6 xDUK, inJ:49578 in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Afw17.01.07.2015 - Curator Note: We had originally associated the body weight QTL 4 identified here, mapping to 55cM on Chr11as Bw4. Bw4 was originally mapped using a different cross, an outbred cross of DU6 x DUK, in J:49578, in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Bw35.04.28.2015 - Curator Note: We had orginally associated the spleen weight QTL 1 identified here, mapping to 55 cM , as Swq1. Swq1 was orignially mapped using a different cross, an outbred cross of DU6 x DUK, in J:49578, in 1998. We consider the current mapping study a separate mapping experiment and have named the QTL identified here as Swq7. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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