Char3^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Char3^C57BL/6
• Name: P. chabaudi malaria resistance QTL 3; C57BL/6
• MGI ID: MGI:3033030
• QTL: Char3 Location: Chr17:34462208-34462345 bp Genetic Position: Chr17, cM position of peak correlated region/allele: 17.98 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers malaria resistance compared to C3H/He. (J:72455)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:72455

Genome scan was performed on 141 (C3H/He x C57BL/6)F2 female animals to identify QTLs associated with malaria resistance. Parental strain C3H/He is susceptible to infection by Plasmodium chabaudi adami whereas parental strain C57BL/6 is resistant. Significant linkage was detected on mouse Chromosome 17 near the H2 locus. This QTL was named Char3 and is closely linked to D17Mit21 at 18.67 cM (LOD=5.0). The C57BL/6-derived allele at Char3 confers decreased parasite load at day 11 post-infection with a dominant mode of inheritance.

Previously mapped QTLs Char1 (D9Mit182) and Char2 (D8Mit33) were also detected in this study.

References

• Original: J:72455 Burt RA, et al., Temporal expression of an H2-linked locus in host response to mouse malaria. Immunogenetics. 1999 Dec;50(5-6):278-85
• All: 1 reference(s)