Ckds^C3HeB/FeJLe
QTL Variant Detail

Summary

• QTL variant: Ckds^C3HeB/FeJLe
• Name: cystic kidney disease severity; C3HeB/FeJLe
• MGI ID: MGI:3033036
• QTL: Ckds Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: C3HeB/FeJLe

Variant description

• Allele Type: QTL
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73583

The oprk mutation (caused by the insertion of transgene TgN737Rpw) on a FVB/N background results in polycystic kidney disease. The same mutation on a C3HeB/FeJLe background results in a less severe polycystic disease phenotype, longer life span, and development of renal cysts at a slower rate compared to the transgenic FVB/N line. Genome scan was performed on a (C3HeB/FeJLe x FVB/N-TgN737Rpw)F1 x FVB/N-TgN737Rpw backcross and (C3HeB/FeJLe x FVB/N-TgN737Rpw)F2 intercross to identify loci modifying polycystic kidney disease severity. A locus on distal chromosome 4 spanning 58 cM - 75 cM was significantly linked to cystic kidney disease severity and was named Ckds. This locus reached LOD = 2.34 in the backcross and LOD = 2.1 in the F2 intercross. FVB/N-derivedalleles confer increased disease severity in a recessive fashion at Ckds.

References

• Original: J:73583 Sommardahl C, et al., Phenotypic variations of orpk mutation and chromosomal localization of modifiers influencing kidney phenotype. Physiol Genomics. 2001 Dec 21;7(2):127-34
• All: 1 reference(s)