Cons4^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Cons4^DBA/2J
• Name: consumption-saccharin intake 4; DBA/2J
• MGI ID: MGI:3033046
• QTL: Cons4 Location: unknown Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50271

841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta9 (P<0.01 at D11Nds1; 43.8 cM) mapped to a region on Chromosome11 spanning 40 cM - 45 cM. Etohcta9 is associated with ethanol-induced taste aversion at high-dose ethanol injection following the paired taste. Taste6 mapped to a region on Chromosome 11 spanning 23 cM - 35 cM and is associated with saccharin preference. Cons4 (P<0.01 at D11Ncvs60) mapped to 74 cM and is associated with preconditioned saccharin intake.

References

• Original: J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• All: 1 reference(s)