Gck^Rgsc272
Chemically induced Allele Detail

Summary

• Symbol: Gck^Rgsc272
• Name: glucokinase; early onset diabetes, 2 RIKEN GSC
• MGI ID: MGI:3033223
• Synonyms: early onset diabetes, 2 RIKEN GSC, Gck^2Rgsc, Gck^M224R, M-272, Rgsc272
• Gene: Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Gck^Rgsc272 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: T to G transversion in exon 6 results in a missense mutation and substitution of arginine for methionine at amino acid 224. Real time PCR on liver samples detected no change in Gck mRNA expression however liver protein levels and Gck activity are reduced (J:88919, J:137483)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gck Mutation: 63 strains or lines available

References

• Original: J:88919 Inoue M, et al., A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program. Hum Mol Genet. 2004 Jun 1;13(11):1147-57
• All: 2 reference(s)