Bub1b^{Gt(neo-btk)1Dai}
Gene trapped Allele Detail

Summary

• Symbol: Bub1b^{Gt(neo-btk)1Dai}
• Name: BUB1B, mitotic checkpoint serine/threonine kinase; gene trap 1, Wei Dai
• MGI ID: MGI:3033386
• Synonyms: BUBR1^-, BubR1^L
• Gene: Bub1b Location: Chr2:118428692-118472072 bp, + strand Genetic Position: Chr2, 59.4 cM
• Alliance: Bub1b^{Gt(neo-btk)1Dai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88223
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The endogenous gene was disrupted by the integration of a gene trap vector into intron 1. The gene trap vector contained a splice acceptor, neo, a polyadenylation signal, PGK-btk, and a a splice donor. (J:88223)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bub1b Mutation: 59 strains or lines available

References

• Original: J:88223 Wang Q, et al., BUBR1 deficiency results in abnormal megakaryopoiesis. Blood. 2004 Feb 15;103(4):1278-85
• All: 5 reference(s)