Fgf23^tm1Tyam
Targeted Allele Detail

Summary

• Symbol: Fgf23^tm1Tyam
• Name: fibroblast growth factor 23; targeted mutation 1, Takeyoshi Yamashita
• MGI ID: MGI:3033408
• Synonyms: Fgf23^-
• Gene: Fgf23 Location: Chr6:127049865-127058371 bp, + strand Genetic Position: Chr6, 61.92 cM
• Alliance: Fgf23^tm1Tyam page

Fgf23^tm1Tyam/Fgf23^tm1Tyam mice display abnormal bone development

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88172
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.2 kb genomic fragment encompassing a 5' portion of exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected in the serum of homozygous mutant mice by ELISA. (J:88172)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf23 Mutation: 18 strains or lines available

References

• Original: J:88172 Shimada T, et al., Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest. 2004 Feb;113(4):561-8
• All: 1 reference(s)