Tlyr1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Tlyr1^C57BL/6J
• Name: thymic lymphoma resistance 1; C57BL/6J
• MGI ID: MGI:3033597
• QTL: Tlyr1 Location: Chr19:20539528-25313796 bp Genetic Position: Chr19, cM position of peak correlated region/allele: 21.34 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to thymic lymphomas compared to M. spretus. (J:79055)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Candidate Genes

J:168370

Three overlapping segments of the Tlyr1 locus resided in three SEG/Pas subcongenic strains. One of these regions proved informative to suggest that Cd274 may be a candidate for the Tlyr1 locus.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:79055

C57BL/6J mice develop thymic lymphomas after acute gamma irradiation, whereas Mus spretus and its F1 hybrids with C57BL/6J appear resistant. Genetic analysis using consomic strains between Mus spretus and C57BL/6J indicated that a locus on mouse Chromosome 19 conferred resistance to thymic lymphomas. Further genetic analysis showed that the locus Tlyr1 can be mapped between D19Mit60 and D19Mit40. Homozygosity for C57BL/6J-derived alleles confer resistance to thymic lymphomas at Tlyr1. Candidate genes mapping near Tlyr1 include Pdcd4, Fas and Pten.

References

• Original: J:79055 Santos J, et al., A new locus for resistance to gamma-radiation-induced thymic lymphoma identified using inter-specific consomic and inter-specific recombinant congenic strains of mice. Oncogene. 2002 Sep 26;21(43):6680-3
• All: 1 reference(s)