Cd276tm1Mak
Targeted Allele Detail
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Symbol: |
Cd276tm1Mak |
Name: |
CD276 antigen; targeted mutation 1, Tak Mak |
MGI ID: |
MGI:3033707 |
Synonyms: |
B7-H3- |
Gene: |
Cd276 Location: Chr9:58431581-58462720 bp, - strand Genetic Position: Chr9, 31.79 cM
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Alliance: |
Cd276tm1Mak page
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Germline Transmission: |
Earliest citation of germline transmission:
J:84973
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Homologous recombination was used to replace a 3.2 kb genomic fragment including the exon encoding the second immunoglobulin domain with a neomycin cassette in antisense orientation relative to transcription. RT-PCR and flow cytometric analysis indicated an absence of transcript and protein, respectively, in homozygous mutant MEFs.
(J:84973)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cd276 Mutation: |
24 strains or lines available
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Original: |
J:84973 Suh WK, et al., The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol. 2003 Sep;4(9):899-906 |
All: |
8 reference(s) |
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