Icmt^tm1Mbrg
Targeted Allele Detail

Summary

• Symbol: Icmt^tm1Mbrg
• Name: isoprenylcysteine carboxyl methyltransferase; targeted mutation 1, Martin O Bergo
• MGI ID: MGI:3033709
• Synonyms: Icmt^flx, Icmt^hm
• Gene: Icmt Location: Chr4:152381684-152391578 bp, + strand Genetic Position: Chr4, 83.02 cM
• Alliance: Icmt^tm1Mbrg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88170
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance gene was inserted upstream of exon 1 while a third loxP site was inserted in intron 1. Expression and activity levels of the encoded protein were 70 to 90% lower than controls. (J:88170)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icmt Mutation: 12 strains or lines available

References

• Original: J:88170 Bergo MO, et al., Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest. 2004 Feb;113(4):539-50
• All: 7 reference(s)