Adh5^tm1Stam
Targeted Allele Detail

Summary

• Symbol: Adh5^tm1Stam
• Name: alcohol dehydrogenase 5 (class III), chi polypeptide; targeted mutation 1, Jonathan S Stamler
• MGI ID: MGI:3033711
• Synonyms: GSNOR^-
• Gene: Adh5 Location: Chr3:138148854-138161260 bp, + strand Genetic Position: Chr3, 64.26 cM
• Alliance: Adh5^tm1Stam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88337
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Homologous recombination was used to replace exons 5 and 6 with a neomycin resistance gene. The deleted region encoded most of the coenzyme binding domain. S-nitrosoglutathione reductase activity was undetected in various tissues obtained from homozygous mutant mice. (J:88337)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adh5 Mutation: 30 strains or lines available

References

• Original: J:88337 Liu L, et al., Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell. 2004 Feb 20;116(4):617-28
• All: 33 reference(s)