Odsm1^A/J
QTL Variant Detail

Summary

• QTL variant: Odsm1^A/J
• Name: ocular degeneration with sex reversal modifier 1; A/J
• MGI ID: MGI:3033745
• QTL: Odsm1 Location: unknown Genetic Position: Chr18, cM position of peak correlated region/allele: 40.14 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to sex reversal compared to FVB/N. (J:82118)

Notes

Homozygosity for A/J-derived alleles at Odsm1 appears to inhibit sex reversal.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:82118

F2 mice from a fertile (AXFVB) F1 XX Ods/F1 female mated to (AXFVB) F1 XY Ods/F1 male were informative in identifying a region of mouse Chromosome 18 that modifies Ods expression. The locus representing this region is identified as Odsm1 and is within aregion defined by markers D18Mit189 and D18Mit210. Authors suggest Madh2 , Madh4 and Madh7 as potential candidates for Odsm1. Homozygosity for FVB/N-derived alleles at Odsm1 appears to favor sex reversal whereas homozygosity for A/J-derived alleles appears to inhibit sex reversal.

References

• Original: J:82118 Qin Y, et al., A major locus on mouse chromosome 18 controls XX sex reversal in Odd Sex (Ods) mice. Hum Mol Genet. 2003 Mar 1;12(5):509-15
• All: 1 reference(s)