Syp^tm1Leu
Targeted Allele Detail

Summary

• Symbol: Syp^tm1Leu
• Name: synaptophysin; targeted mutation 1, Rudolf E Leube
• MGI ID: MGI:3033781
• Synonyms: SPH^-
• Gene: Syp Location: ChrX:7504819-7519495 bp, + strand Genetic Position: ChrX, 3.44 cM, cytoband A-D
• Alliance: Syp^tm1Leu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30488
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 2. Northern blot analysis on RNA derived from brain tissue of homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:30488)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syp Mutation: 22 strains or lines available

References

• Original: J:30488 Eshkind LG, et al., Mice lacking synaptophysin reproduce and form typical synaptic vesicles. Cell Tissue Res. 1995 Dec;282(3):423-33
• All: 11 reference(s)