Oss1^CBA/Ca
QTL Variant Detail

Summary

• QTL variant: Oss1^CBA/Ca
• Name: osteosarcoma suppressor 1; CBA/Ca
• MGI ID: MGI:3033785
• QTL: Oss1 Location: unknown Genetic Position: Chr9, Syntenic

Variant origin

• Strain of Specimen: CBA/Ca

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:78944

177 polymorphic markers were screened in 18 radioisotope-induced osteosarcoma samples from (BALB/c x CBA/CA)F1 animals. Two loci mapped to mouse Chromosome 9 with high levels (78%) of allelic imbalance (AI). Oss1 (osteosarcoma suppressor 1) spans 48 cM -49 cM, and Oss2 spans 35 cM - 45 cM on mouse Chromosome 9. Oss1 is syntenic to human OSS1 on 6q14, and Oss2 is syntenic to human OSS2 on 15q21.

References

• Original: J:78944 Nathrath MH, et al., Two novel tumor suppressor gene loci on chromosome 6q and 15q in human osteosarcoma identified through comparative study of allelic imbalances in mouse and man. Oncogene. 2002 Aug 29;21(38):5975-80
• All: 1 reference(s)