Sluc15^B10.O20/Dem
QTL Variant Detail

Summary

• QTL variant: Sluc15^B10.O20/Dem
• Name: susceptibility to lung cancer 15; B10.O20/Dem
• MGI ID: MGI:3033798
• QTL: Sluc15 Location: Chr1:36065351-36065454 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: B10.O20/Dem

Variant description

• Allele Type: QTL

Notes

Animals homozygous for B10.O20/Dem-derived alleles at Sluc15 and homozygous for O20/A-derived alleles at Sluc23 exhibit decreased lung tumor size.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:71973

Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.

In the (OcB3 x O20/A)F2 cross a newly identified QTL, Sluc15, was mapped to mouse Chromosome 1 in linkage to D1Mit170 at approximately 19.5 cM.

References

• Original: J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• All: 1 reference(s)