Sluc17^B10.O20/Dem
QTL Variant Detail

Summary

• QTL variant: Sluc17^B10.O20/Dem
• Name: susceptibility to lung cancer 17; B10.O20/Dem
• MGI ID: MGI:3033802
• QTL: Sluc17 Location: Chr2:179433493-179433627 bp Genetic Position: Chr2, cM position of peak correlated region/allele: 102.29 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: B10.O20/Dem

Variant description

• Allele Type: QTL

Notes

Animals homozygous for B10.O20/Dem-derived alleles at Sluc17 and homozygous for O20/A-derived alleles at Sluc20 exhibit reduced lung tumor size.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:71973

Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.

In the (OcB4 x O20/A)F2 cross newly identified QTL Sluc16 mapped to mouse Chr 2 in linkage with D2Mit5 at approximately 5 cM.

In the (OcB16 x O20/A)F2 cross newly identified QTL Sluc17, also mapped to mouse Chr 2 in linkage with D2Mit200 at approximately 107 cM.

References

• Original: J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• All: 1 reference(s)