Sluc22^O20/A
QTL Variant Detail

Summary

• QTL variant: Sluc22^O20/A
• Name: susceptibility to lung cancer 22; O20/A
• MGI ID: MGI:3033812
• QTL: Sluc22 Location: Chr10:103713608-103713756 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 54.72 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: O20/A

Variant description

• Allele Type: QTL

Notes

Sluc22 participates in additive interactions with other Sluc loci.

Animals homozygous for B10.O20/Dem-derived alleles at Sluc12 and homozygous for O20/A-derived alleles at Sluc22 exhibit decreased lung tumor size.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:71973

Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.

In the (OcB16 x O20/A)F2 cross a newly identified QTL Sluc22 mapped to Chr 10 in linkage with D10Mit122 at approximately 61.0cM.

In the (OcB4 x O20/A) F2 cross newly identified QTL Sluc29 mapped to mouse Chr 10 in linkage with D10Mit28 at approximately 4 cM.

References

• Original: J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• All: 1 reference(s)