Sluc20^O20/A
QTL Variant Detail

Summary

• QTL variant: Sluc20^O20/A
• Name: susceptibility to lung cancer 20; O20/A
• MGI ID: MGI:3033816
• QTL: Sluc20 Location: Chr8:25103201-25103372 bp Genetic Position: Chr8, cM position of peak correlated region/allele: 12.86 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: O20/A

Variant description

• Allele Type: QTL

Tumor Data

List all tumor models in MMHCdb carrying Sluc20^O20/A

Notes

Sluc20 interacts with Sluc1 on mouse Chromosome 19. Animals homozygous for O20/A-derived alleles at both Sluc1 and Sluc20 exhibit increased lung tumor size.

Sluc20 interacts with Sluc 17 on mouse Chromosome 2. Animals homozygous for B10.O20/Dem-derived alleles at Sluc17 and homozygous for O20/A-derived alleles at Sluc20 exhibit reduced lung tumor size.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:71973

Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.

In the (OcB9 x O20/A)F2 cross a newly identified QTL, Sluc20, mapped to mouse Chr 8 in linkage to D8Mit3 at approximately 10 cM.

References

• Original: J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• All: 2 reference(s)