Sluc20^B10.O20/Dem
QTL Variant Detail

Summary

• QTL variant: Sluc20^B10.O20/Dem
• Name: susceptibility to lung cancer 20; B10.O20/Dem
• MGI ID: MGI:3033817
• QTL: Sluc20 Location: Chr8:25103201-25103372 bp Genetic Position: Chr8, cM position of peak correlated region/allele: 12.86 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: B10.O20/Dem

Variant description

• Allele Type: QTL

Tumor Data

List all tumor models in MMHCdb carrying Sluc20^B10.O20/Dem

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:71973

Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.

In the (OcB9 x O20/A)F2 cross a newly identified QTL, Sluc20, mapped to mouse Chr 8 in linkage to D8Mit3 at approximately 10 cM.

References

• Original: J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• All: 2 reference(s)