Sluc24^O20/A
QTL Variant Detail

Summary

• QTL variant: Sluc24^O20/A
• Name: susceptibility to lung cancer 24; O20/A
• MGI ID: MGI:3033820
• QTL: Sluc24 Location: Chr15:3489694-3489829 bp Genetic Position: Chr15, cM position of peak correlated region/allele: 1.84 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: O20/A

Variant description

• Allele Type: QTL

Notes

Sluc24 participates in additive interactions with other Sluc loci.

Animals homozygous for O20/A-derived alleles at Sluc5 and Sluc24 exhibit decreased lung tumor size.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:71973

Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.

In the (OcB16 x O20/A)F2 cross a newly identified QTL, Sluc24, mapped to Chr 15 in linkage with D15Mit13 at approximately 6.7 cM.

In the (OcB4 x O20/A)F2 cross newly identified QTL, Sluc25, mapped to Chr 15 in linkage with D15Nds3 at approximately 32.0cM. In the same cross, Sluc26, mapped to mouse Chr 15 in linkage with D15Mit96 at approximately 48.9 cM.

References

• Original: J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• All: 1 reference(s)