Sluc27^O20/A
QTL Variant Detail

Summary

• QTL variant: Sluc27^O20/A
• Name: susceptibility to lung cancer 27; O20/A
• MGI ID: MGI:3033826
• QTL: Sluc27 Location: Chr16:78608644-78608764 bp Genetic Position: Chr16, cM position of peak correlated region/allele: 45.36 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: O20/A

Variant description

• Allele Type: QTL

Notes

Sluc27 interacts with Sluc19 on mouse Chromosome 7.

Animals homozygous for B10.O20/Dem-derived alleles at Sluc19 and homozygous for O20/A-derived alleles at Sluc27 exhibit increased lung tumor size.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:71973

Several F2 crosses between inbred strain O20/A and recombinant congenic strains OcB-3/Dem, OcB-4/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem were used to map QTLs linked to lung tumor susceptibility. Parental strain O20/A and OcB-4/Dem are susceptible to lung tumor development after ENU treatment whereas parental strains OcB-3/Dem, OcB-6/Dem, OcB-9/Dem, and OcB-16/Dem are relatively resistant. 14 previously identified lung tumor susceptibility loci were detected in these crosses (Sluc1-Sluc14) and 16 new loci were identified with a statistical significance of P>0.05. All of the QTL were detected in pairwise interactions, Table 1, Fig 1.

In (OcB16 x O20/A)F2 a newly identified QTL, Sluc27, mapped to mouse Chr 16 in linkage with D16Mit19 at approximately 54 cM.

References

• Original: J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• All: 1 reference(s)