Sluc1^O20/A
QTL Variant Detail

Summary

• QTL variant: Sluc1^O20/A
• Name: susceptibility to lung cancer 1; O20/A
• MGI ID: MGI:3033830
• QTL: Sluc1 Location: Chr19:36016944-46761521 bp Genetic Position: Chr19, Syntenic

Variant origin

• Strain of Specimen: O20/A

Variant description

• Allele Type: QTL

Notes

Sluc1 interacts with Sluc20 on mouse Chromosome 8. Animals homozygous for O20/A-derived alleles at both Sluc1 and Sluc20 exhibit increased lung tumor size.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:36997

Lung tissue of N-ethyl-N-nitrosourea treated F2 progeny of an (OcB9/Dem x O20/A)F1 intercross was microscopically analyzed for the presence and size of tumors. The progeny were genotyped by PCR. Statistical analysis indicated the presence of a locus influencing susceptibility to lung cancer (Sluc1) on mouse Chromosome 19, distal to the Pas3 region (flanked by D19Mit42 and D19Mit19). The QTL likelihood plot indicates a peak near D19Mit9. The following order of loci was reported: D19Mit42 - D19Mit61- D19Mit63 - D19Mit19 - Sluc1 - D19Mit9 - D19Mit33.

References

• Original: J:71973 Tripodis N, et al., Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J Natl Cancer Inst. 2001 Oct 3;93(19):1484-91
• All: 1 reference(s)