Loxl1^tm1Tili
Targeted Allele Detail

Summary

• Symbol: Loxl1^tm1Tili
• Name: lysyl oxidase-like 1; targeted mutation 1, Tiansen Li
• MGI ID: MGI:3033883
• Synonyms: Loxl1^-
• Gene: Loxl1 Location: Chr9:58195021-58220469 bp, - strand Genetic Position: Chr9, 31.65 cM
• Alliance: Loxl1^tm1Tili page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88284
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 1 was disrupted by the insertion of a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of homozygous mutant aorta extracts. (J:88284)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Loxl1 Mutation: 35 strains or lines available

References

• Original: J:88284 Liu X, et al., Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet. 2004 Feb;36(2):178-82
• All: 9 reference(s)