Vsx1^tm1Mci
Targeted Allele Detail

Summary

• Symbol: Vsx1^tm1Mci
• Name: visual system homeobox 1; targeted mutation 1, Roderick R McInnes
• MGI ID: MGI:3033929
• Synonyms: Vsx1 delta 1-4
• Gene: Vsx1 Location: Chr2:150522622-150531057 bp, - strand Genetic Position: Chr2, 74.74 cM
• Alliance: Vsx1^tm1Mci page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88182
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment, encompassing a portion of exon 1 and all of exons 2 through 4, was replaced with a neomycin selection cassette inserted by homologous recombination. 86 bp of the exon 1 coding region, as well as the coding region of exon 5, were left intact, however no protein was detected in homozygous mutant retinal tissue by immunofluorescence. (J:88182)

Disease models

Expression

In Mice Carrying this Mutation:

20 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vsx1 Mutation: 11 strains or lines available

References

• Original: J:88182 Chow RL, et al., Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1754-9
• All: 5 reference(s)