Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:72857Polymorphic markers were screened in two different complex crosses to identify QTLs associated with increased lifespan. Leg1, a QTL exhbiting significant linkage (P = 5.4 x 10-5) to longevity, was detected on mouse Chromosome 8 in a (LP/J x MOLD/Rk)F1 x (NZW/LacJ x BALB/cBy)F1 population. Leg1 spans approximately 7.5 cM - 12.5 cM on mouse Chromosome 8 and is associated with markers D8Mit290 and D8Mit171. MOLD/Rk-derived alleles confer increased longevity by 110 days at Leg1. On mouse Chromosome 10, a QTL associated with longevity (P = 2.6 x 10-5), Leg2, was identified in a (ST/bJ x C57BL/6J)F1 x (CAST/Ei x DBA/2J)F1 population. Leg2 spans approximately 65 cM - 70 cM on mouse Chromosome 10 and is associated with marker D10Mit267. CAST/Ei-derived alleles confer increased longevity by 110 days at Leg2. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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