Leg2^CAST/Ei
QTL Variant Detail

Summary

• QTL variant: Leg2^CAST/Ei
• Name: longevity extending gene 2; CAST/Ei
• MGI ID: MGI:3033951
• QTL: Leg2 Location: Chr10:119506908-119507010 bp Genetic Position: Chr10, cM position of peak correlated region/allele: 67.55 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: CAST/Ei

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased longevity by 110 days compared to C57BL/6J, DBA/2J, and ST/bJ. (J:72857)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:72857

Polymorphic markers were screened in two different complex crosses to identify QTLs associated with increased lifespan. Leg1, a QTL exhbiting significant linkage (P = 5.4 x 10^-5) to longevity, was detected on mouse Chromosome 8 in a (LP/J x MOLD/Rk)F1 x (NZW/LacJ x BALB/cBy)F1 population. Leg1 spans approximately 7.5 cM - 12.5 cM on mouse Chromosome 8 and is associated with markers D8Mit290 and D8Mit171. MOLD/Rk-derived alleles confer increased longevity by 110 days at Leg1. On mouse Chromosome 10, a QTL associated with longevity (P=2.6 x 10^-5), Leg2, was identified in a (ST/bJ x C57BL/6J)F1 x (CAST/Ei x DBA/2J)F1 population. Leg2 spans approximately 65 cM - 70 cM on mouse Chromosome 10 and is associated with marker D10Mit267. CAST/Ei-derived alleles confer increased longevity by 110 days at Leg2.

References

• Original: J:72857 Klebanov S, et al., Maximum life spans in mice are extended by wild strain alleles. Exp Biol Med (Maywood). 2001 Oct;226(9):854-9
• All: 1 reference(s)