Ar^tm1Verh
Targeted Allele Detail

Summary

• Symbol: Ar^tm1Verh
• Name: androgen receptor; targeted mutation 1, Guido Verhoeven
• MGI ID: MGI:3034098
• Synonyms: AR^fl, AR^flox, ARflox, AR^{loxP-exon2-loxP}
• Gene: Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
• Alliance: Ar^tm1Verh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88169
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 2 was flanked by single loxP sites in introns 1 and 2. (J:88169)

Disease models

Expression

In Mice Carrying this Mutation:	42 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ar Mutation: 23 strains or lines available

References

• Original: J:88169 De Gendt K, et al., A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1327-32
• All: 100 reference(s)