Nox3^het-R96
Chemically induced Allele Detail

Summary

• Symbol: Nox3^het-R96
• Name: NADPH oxidase 3; head tilt R96
• MGI ID: MGI:3034161
• Gene: Nox3 Location: Chr17:3685515-3746536 bp, - strand Genetic Position: Chr17, 2.05 cM
• Alliance: Nox3^het-R96 page

Mutation origin

• Strain of Origin: C3H

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation in the R96 mouse was identified as a T-to-A nonsense mutation at coding nucleotide position 381 (c.381T>A), changing tyrosine codon 127 to a stop codon (p.Y127*). The resulting protein, if produced, would be truncated, lacking most of the relevant feature of NADPH oxidases and would be non-functional. (J:89010)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nox3 Mutation: 38 strains or lines available

References

• Original: J:89010 Paffenholz R, et al., Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase. Genes Dev. 2004 Mar 1;18(5):486-91
• All: 1 reference(s)