Nox3^het-R542
Chemically induced Allele Detail

Summary

• Symbol: Nox3^het-R542
• Name: NADPH oxidase 3; head tilt R542
• MGI ID: MGI:3034162
• Gene: Nox3 Location: Chr17:3685515-3746536 bp, - strand Genetic Position: Chr17, 2.05 cM
• Alliance: Nox3^het-R542 page

Mutation origin

• Strain of Origin: C3H

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation in the R542 mouse was identified as an A-to-G substitution at coding nucleotide position 1516 (c.1516A>G), replacing a lysine residue with a glutamic acid at postion 506 (p.K506E). The lysine residue is part of the putative NADPH binding site. (J:89010)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nox3 Mutation: 38 strains or lines available

References

• Original: J:89010 Paffenholz R, et al., Vestibular defects in head-tilt mice result from mutations in Nox3, encoding an NADPH oxidase. Genes Dev. 2004 Mar 1;18(5):486-91
• All: 1 reference(s)