Lmo3^tm2Thr
Targeted Allele Detail

Summary

• Symbol: Lmo3^tm2Thr
• Name: LIM domain only 3; targeted mutation 2, Terence H Rabbitts
• MGI ID: MGI:3035825
• Synonyms: Lmo3^z
• Gene: Lmo3 Location: Chr6:138339916-138558966 bp, - strand Genetic Position: Chr6, 69.02 cM
• Alliance: Lmo3^tm2Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88167
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a beta galactosidase reporter. The targeting vector contained an IRES-lacZ gene plus the simian virus 40 polyadenylation site followed by the neomycin cassette. Brain dissection and whole mount stained with X-Gal revealed beta galactosidase expression. (J:88167)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lmo3 Mutation: 14 strains or lines available

References

• Original: J:88167 Tse E, et al., Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice. Mol Cell Biol. 2004 Mar;24(5):2063-73
• All: 5 reference(s)