Lmo4^tm1Thr
Targeted Allele Detail

Summary

• Symbol: Lmo4^tm1Thr
• Name: LIM domain only 4; targeted mutation 1, Terence H Rabbitts
• MGI ID: MGI:3035826
• Synonyms: Lmo4^-
• Gene: Lmo4 Location: Chr3:143894291-143910981 bp, - strand Genetic Position: Chr3, 68.61 cM
• Alliance: Lmo4^tm1Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88167
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 2 by homologous recombination, precluding the translation of any endogenous sequence other than that encoding the first 15 amino acids of the protein. The absence of endogenous transcript was indicated by Northern blot analysis of mutant embryos. (J:88167)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmo4 Mutation: 9 strains or lines available

References

• Original: J:88167 Tse E, et al., Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice. Mol Cell Biol. 2004 Mar;24(5):2063-73
• All: 5 reference(s)