Lmo4^tm2Thr
Targeted Allele Detail

Summary

• Symbol: Lmo4^tm2Thr
• Name: LIM domain only 4; targeted mutation 2, Terence H Rabbitts
• MGI ID: MGI:3035827
• Synonyms: Lmo4-GFP, Lmo4^z
• Gene: Lmo4 Location: Chr3:143894291-143910981 bp, - strand Genetic Position: Chr3, 68.61 cM
• Alliance: Lmo4^tm2Thr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88167
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A targeting vector was used to create an in-frame fusion of a 5' portion of exon 2 and a GFP-hygro cassette. The absence of endogenous transcript was indicated by Northern blot analysis of mutant embryos. (J:88167)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmo4 Mutation: 9 strains or lines available

References

• Original: J:88167 Tse E, et al., Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice. Mol Cell Biol. 2004 Mar;24(5):2063-73
• All: 1 reference(s)