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Lmo4tm3Sho
Targeted Allele Detail
Summary
Symbol: Lmo4tm3Sho
Name: LIM domain only 4; targeted mutation 3, Stuart Orkin
MGI ID: MGI:3035916
Synonyms: Lmo4:LacZ
Gene: Lmo4  Location: Chr3:143894291-143910981 bp, - strand  Genetic Position: Chr3, 68.61 cM
Alliance: Lmo4tm3Sho page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:88168
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ gene was inserted in frame with the translation initiation codon of exon 2 and was followed by a floxed PGK-neomycin resistance gene and thus completely replacing exon 2. Chimeric mice were crossed with cre expressing transgenic mice leading to the excision of the floxed neomycin gene. Beta-galactosidase was expressed from this allele. (J:88168)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 37 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmo4 Mutation:  9 strains or lines available
References
Original:  J:88168 Hahm K, et al., Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol. 2004 Mar;24(5):2074-82
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory