Deaf1^tm1Sho
Targeted Allele Detail

Summary

• Symbol: Deaf1^tm1Sho
• Name: DEAF1, transcription factor; targeted mutation 1, Stuart Orkin
• MGI ID: MGI:3035918
• Synonyms: Deaf-1^-
• Gene: Deaf1 Location: Chr7:140877093-140907603 bp, - strand Genetic Position: Chr7, 86.61 cM
• Alliance: Deaf1^tm1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88168
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Two exons coding for amino acids 192 to 269 were replaced by a floxed PGK-neomycin resistance cassette. Neomycin was subsequently excised by mating chimeric mice to cre-expressing transgenic mice. (J:88168)

Expression

In Mice Carrying this Mutation:	3 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Deaf1 Mutation: 27 strains or lines available

References

• Original: J:88168 Hahm K, et al., Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol. 2004 Mar;24(5):2074-82
• All: 7 reference(s)