Grip2^tm1Rha
Targeted Allele Detail

Summary

• Symbol: Grip2^tm1Rha
• Name: glutamate receptor interacting protein 2; targeted mutation 1, Ralf H Adams
• MGI ID: MGI:3035933
• Synonyms: Grip2^-
• Gene: Grip2 Location: Chr6:91738490-91804231 bp, - strand Genetic Position: Chr6, 40.8 cM, cytoband D2
• Alliance: Grip2^tm1Rha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88266
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An exon encoding the PDZ1 domain was disrupted by the insertion of a neomycin cassette. Protein was undetected by Western blot analysis of whole brain lysates obtained from homozygous neonates. (J:88266)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grip2 Mutation: 35 strains or lines available

References

• Original: J:88266 Takamiya K, et al., A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1. Nat Genet. 2004 Feb;36(2):172-7
• All: 9 reference(s)