Opfa^Boulder
QTL Variant Detail

Summary

• QTL variant: Opfa^Boulder
• Name: open field activity; Boulder
• MGI ID: MGI:3036093
• QTL: Opfa Location: Chr1:161531347-161531592 bp Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: Boulder heterogeneous stock

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:82705

Previous studies identified a QTL on central mouse Chromosome 1 associated with conditioned fear response (Wehner et al. 1997; Caldarone et al. 1997). In this study, Boulder and Northport heterogeneous stock (HS) animals were genotyped for markers on chromosome 1 to analyze this region in detail. Parental strain Boulder HS is composed of C57BL/6, BALB/c, RIII, AKR, DBA/2, I, A/J, and C3H and has been bred for more than 60 generations. Parental strain Northport HS has been bred for more than 40 generations and is composed of A/J, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/2J, and LP/J. Peak linkage for contextual fear conditioning, Cfcd, mapped between D1Mit370 (88.3 cM) and D1Mit36 (92.3 cM) with LOD=5.5 in the Boulder HS. Linkage to open field activitywas also examined and did not map to the same location. Open field activity, Opfa, mapped to 81.6 cM at D1Mit266, with LOD=5.4 in the Northport HS and LOD=3.3 in the Boulder HS.

References

• Original: J:82705 Talbot CJ, et al., Fine scale mapping of a genetic locus for conditioned fear. Mamm Genome. 2003 Apr;14(4):223-30
• All: 1 reference(s)