Pctr2^DBA/2N
QTL Variant Detail

Summary

• QTL variant: Pctr2^DBA/2N
• Name: plasmacytoma resistance 2; DBA/2N
• MGI ID: MGI:3036108
• QTL: Pctr2 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: DBA/2N

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers partial plasmacytoma resistance compared to BALB/cAnPt. (J:16958)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Candidate Genes

J:86978

A Congenic strain between BALB/cAn and DBA/2N ( C.D2-Fv1B) was constructed to exclude Xmv8 and Xmv44 from consideration as candidates for Pctr2. Using C.D2-Fv1B the authors were able to refine the region containing Pctr2 to D4Mit310 and D4Mit129. Further a region 86 kb distal of Fbxo6b was identified as the proximal interval of Pctr2. Using the MIT markers BAC clones were isolated for the purpose of identifying polymorphisms in genes that could be potential candidates for Pctr2. Polymorphisms between BALB/cAn and DBA/2N resulting in AA changes in the Frap1 genes are suggestive as causative of the Pctr2 phenotype.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:16958

BALB/cAnPt mice are susceptibile to plasmacytomas whereas DBA/J mice are resistant. Genetic resistance to plasmacytomas was studied in mice made congenic between BALB/cAnPt and DBA/2N in which chromatin from DBA/2N was transferred to the BALB/cAnPt background. Two regions on Chromosome 4 of DBA/2 are involved in a partial resistant phenotype.

The first region defined by congenics C.D2-Tf3, C.D2-D4Lgm1A, C.D2-D4Lgm1b, C.D2-D4Lgm1C and C.D2-D4Lgm1H is bounded by Ifa and D4Rck41 and is designated Cdkn2a.

The second region defined by congenics C.D2 Fv1 and C.D2 Pnd7 is bounded by Tnfrsf1b and D4Smh6b and designated Pctr2.

References

• Original: J:16958 Potter M, et al., Identification of two genes on chromosome 4 that determine resistance to plasmacytoma induction in mice. Cancer Res. 1994 Feb 15;54(4):969-75
• All: 1 reference(s)