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PkcclC57BL/6J
QTL Variant Detail
Summary
QTL variant: PkcclC57BL/6J
Name: protein kinase C content in lungs; C57BL/6J
MGI ID: MGI:3036116
QTL: Pkccl  Location: Chr11:108604608-108604732 bp  Genetic Position: Chr11, cM position of peak correlated region/allele: 71.83 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:63984

23 AXB and BXA (A=A/J; B=C57BL/6J) recombinant inbred (RI) strains were mapped for QTLs associated with protein kinase C activity and protein kinase C content in the lungs, both of which are traits associated with susceptibility to asthma and adenocarcinoma of the lung. Progenitor strain A/J exhibits low protein kinase C activity and protein kinase C content in the lungs of adult mice, and is susceptible to both spontaneous and experimentally induced lung adenomas. In contrast, progenitor strain C57BL/6Jexhibits higher protein kinase C activity and protein kinase C content than A/J, and is resistant to spontaneous and experimentally induced lung adenomas. A locus associated with protein kinase C activity mapped to approximately 88 cM on mouse Chromosome 3 with a peak LRS score of 15.4 at D3Mit19. This locus, Pkcal (protein kinase C activity in lungs), is also associated with protein kinase C content with a suggestive LRS score of 6.2. D3Mit94 (at approximately 22 cM) and D3Mit141 (at approximately 45.2 cM) on mouse Chromosome 3 were suggestively associated with protein kinase C activity. A locus associated with protein kinase C content mapped to approximately 68 cM on mouse Chromosome 11 with a peak LRS score of 12.5 at D11Mit333. This locus, Pkccl (protein kinase C content in lungs), maps near the protein kinase C, alpha gene (Prkca) and is also associated with protein kinase C activity with a suggestive LRS score of 5.1.

References
Original:  J:63984 Dwyer-Nield LD, et al., Quantitative trait locus mapping of genes regulating pulmonary PKC activity and PKC-alpha content. Am J Physiol Lung Cell Mol Physiol. 2000 Aug;279(2):L326-32
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory