Il23a^tm1Ngh
Targeted Allele Detail

Summary

• Symbol: Il23a^tm1Ngh
• Name: interleukin 23, alpha subunit p19; targeted mutation 1, Nico Ghilardi
• MGI ID: MGI:3036163
• Synonyms: Il-23p19^-, p35/19^-
• Gene: Il23a Location: Chr10:128132009-128133953 bp, - strand Genetic Position: Chr10, 76.51 cM, cytoband D3
• Alliance: Il23a^tm1Ngh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88235
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with an EGFP reporter gene followed by a PGK-neomycin resistance cassette. The pattern of EGFP expression was similar to the endogenous transcript. (J:88235)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il23a Mutation: 27 strains or lines available

References

• Original: J:88235 Ghilardi N, et al., Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol. 2004 Mar 1;172(5):2827-33
• All: 65 reference(s)