Tcf4^tm1Hmb
Targeted Allele Detail

Summary

• Symbol: Tcf4^tm1Hmb
• Name: transcription factor 4; targeted mutation 1, Dan Holmberg
• MGI ID: MGI:3036170
• Synonyms: E2-2^lox, Itf2^fl
• Gene: Tcf4 Location: Chr18:69476500-69821038 bp, + strand Genetic Position: Chr18, 43.23 cM, cytoband E2
• Alliance: Tcf4^tm1Hmb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65236
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The exons encoding the bHLH and C-terminal domains were flanked by loxP sites inserted by homologous recombination in ES cells. (J:65236)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcf4 Mutation: 58 strains or lines available

References

• Original: J:65236 Bergqvist I, et al., The basic helix-loop-helix transcription factor E2-2 is involved in T lymphocyte development. Eur J Immunol. 2000 Oct;30(10):2857-63
• All: 19 reference(s)