Tg(Kit-cre)143Hmb
Transgene Detail

Summary

• Symbol: Tg(Kit-cre)143Hmb
• Name: transgene insertion 143, Dan Holmberg
• MGI ID: MGI:3036304
• Synonyms: c-kit (143) Cre Tg
• Transgene: Tg(Kit-cre)143Hmb Location: unknown
• Alliance: Tg(Kit-cre)143Hmb page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Kit-cre)143Hmb expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Kit (MGI:96677)

• Mutation details: This transgene expresses Cre recombinase under the control of a mouse Kit promoter. In this line, expression of cre was noted in late spermatogenesis, oogenesis and early embryogenesis. Functional analysis of recombinase activity determined that deletion of a floxed reporter gene occurred in a mosaic pattern in all tissues tested. The degree of mosaicism was consistent within an individual, but varied dramatically between individuals. (J:88598)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Kit (mouse) Summary of all recombinase alleles driven by Kit. Comparative matrix view of recombinase activities Alliance mouse Kit gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88598 Bergqvist I, et al., Transgenic Cre recombinase expression in germ cells and early embryogenesis directs homogeneous and ubiquitous deletion of loxP-flanked gene segments. FEBS Lett. 1998 Oct 30;438(1-2):76-80
• All: 2 reference(s)