Ddb2^tm1Linn
Targeted Allele Detail

Summary

• Symbol: Ddb2^tm1Linn
• Name: damage specific DNA binding protein 2; targeted mutation 1, Stuart Linn
• MGI ID: MGI:3036308
• Synonyms: Ddb2^-
• Gene: Ddb2 Location: Chr2:91041917-91067327 bp, - strand Genetic Position: Chr2, 50.56 cM, cytoband E1
• Alliance: Ddb2^tm1Linn page

Tumorigenesis analysis and Hisptopathological images

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88125
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 7 were replaced with a neomycin selection cassette via homologous recombination. The absence of expression in homozygous mutant MEFs was confirmed by RT-PCR and Western blot analysis. (J:88125)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ddb2^tm1Linn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddb2 Mutation: 38 strains or lines available

References

• Original: J:88125 Itoh T, et al., DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2052-7
• All: 2 reference(s)