Tg(Bcl2)ACap
Transgene Detail

Summary

• Symbol: Tg(Bcl2)ACap
• Name: transgene insertion A, Yassemi Capetanaki
• MGI ID: MGI:3036319
• Transgene: Tg(Bcl2)ACap Location: unknown
• Alliance: Tg(Bcl2)ACap page

Cardiac fibrosis and calcification seen in Des^tm1Cap/Des^tm1Cap mice is reduced in Des^tm1Cap/Des^tm1Cap Tg(Bcl2)ACap/Tg(Bcl2)ACap and Des^tm1Cap/Des^tm1Cap Tg(Bcl2)BCap/Tg(Bcl2)BCap mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Bcl2)ACap expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Bcl2 (MGI:88138)

• Mutation details: A murine Bcl2 cDNA was adjoined to a cardiac-specific alpha myosin heavy chain promoter. Western blot analysis indicated strong overexpression of the Bcl2 protein product. This line expresses at a lower level than Tg(Bcl2)BCap. (J:88267)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:88267 Weisleder N, et al., Bcl-2 overexpression corrects mitochondrial defects and ameliorates inherited desmin null cardiomyopathy. Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):769-74
• All: 1 reference(s)