Slc25a4^tm2Dwa
Targeted Allele Detail

Summary

• Symbol: Slc25a4^tm2Dwa
• Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4; targeted mutation 2, Douglas C Wallace
• MGI ID: MGI:3036342
• Synonyms: Ant1^PGKneo
• Gene: Slc25a4 Location: Chr8:46660205-46664099 bp, - strand Genetic Position: Chr8, 26.22 cM
• Alliance: Slc25a4^tm2Dwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41256
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin gene replaced exons 1-3. Northern blot analysis demonstrated the absence of mRNA transcript while protein product was undetectable by Western blot. (J:41256)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc25a4 Mutation: 17 strains or lines available

References

• Original: J:41256 Graham BH, et al., A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Nat Genet. 1997 Jul;16(3):226-34
• All: 11 reference(s)