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SlthsrC57BL/6J
QTL Variant Detail
Summary
QTL variant: SlthsrC57BL/6J
Name: semilethal sex-restricted; C57BL/6J
MGI ID: MGI:3036493
QTL: Slthsr  Location: unknown  Genetic Position: Chr11, cM position of peak correlated region/allele: 51.34 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50198

Backcross offspring from reciprocal matings between (C57BL/6J x DBA/2J)F1 and C57BL/6J animals were typed for a locus on chromosome 11, Slthsr, at position 28 cM - 47 cM (using markers D11Mit78, D11Mit140, D11Mit219, D11Mit40, D11Mit195, and D11Mit199) associated with female-specific non-Mendelian inheritance. Female N2 offspring preferentially inherit C57BL/6J alleles at a frequency of 64%, with strongest association at D11Mit195 (47cM), while male animals inherit C57BL/6J and DBA/2J alleles in a Mendelian fashion (50/50). This locus may contribute to sex differential offspring viability, possibly the result of imprinting at Slthsr or the incompatibility of interacting cytoplasmic factors that is dependent on maternal genotype and the genotype of the developing embryo. Slthsr maps to the same region as Om, a gene involved in early embryonic lethality, and Alcp2, a QTL involved in alcohol preference. The authors hypothesize Om may be responsible for semilethality in the N2 female offspring.

References
Original:  J:50198 Shendure J, et al., Sex-restricted non-Mendelian inheritance of mouse chromosome 11 in the offspring of crosses between C57BL/6J and (C57BL/6J x DBA/2J)F1 mice. Mamm Genome. 1998 Oct;9(10):812-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory