Slthsr^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Slthsr^DBA/2J
• Name: semilethal sex-restricted; DBA/2J
• MGI ID: MGI:3036494
• QTL: Slthsr Location: unknown Genetic Position: Chr11, cM position of peak correlated region/allele: 51.34 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:50198

Backcross offspring from reciprocal matings between (C57BL/6J x DBA/2J)F1 and C57BL/6J animals were typed for a locus on chromosome 11, Slthsr, at position 28 cM - 47 cM (using markers D11Mit78, D11Mit140, D11Mit219, D11Mit40, D11Mit195, and D11Mit199) associated with female-specific non-Mendelian inheritance. Female N2 offspring preferentially inherit C57BL/6J alleles at a frequency of 64%, with strongest association at D11Mit195 (47cM), while male animals inherit C57BL/6J and DBA/2J alleles in a Mendelian fashion (50/50). This locus may contribute to sex differential offspring viability, possibly the result of imprinting at Slthsr or the incompatibility of interacting cytoplasmic factors that is dependent on maternal genotype and the genotype of the developing embryo. Slthsr maps to the same region as Om, a gene involved in early embryonic lethality, and Alcp2, a QTL involved in alcohol preference. The authors hypothesize Om may be responsible for semilethality in the N2 female offspring.

References

• Original: J:50198 Shendure J, et al., Sex-restricted non-Mendelian inheritance of mouse chromosome 11 in the offspring of crosses between C57BL/6J and (C57BL/6J x DBA/2J)F1 mice. Mamm Genome. 1998 Oct;9(10):812-5
• All: 1 reference(s)