Runx1^tm1.1Soga
Targeted Allele Detail

Summary

• Symbol: Runx1^tm1.1Soga
• Name: runt related transcription factor 1; targeted mutation 1.1, Seishi Ogawa
• MGI ID: MGI:3036557
• Synonyms: Aml1^delta, Runx1^-
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^tm1.1Soga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88511
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site was left in place of exon 5 and its flanking sequence after cre-mediated recombination in the germline. (J:88511)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 34 strains or lines available

References

• Original: J:88511 Ichikawa M, et al., AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med. 2004 Apr;10(3):299-304
• All: 3 reference(s)