Fbxw7^tm1Kin
Targeted Allele Detail

Summary

• Symbol: Fbxw7^tm1Kin
• Name: F-box and WD-40 domain protein 7; targeted mutation 1, Kei-ichi Nakayama
• MGI ID: MGI:3036571
• Synonyms: Fbw7^-
• Gene: Fbxw7 Location: Chr3:84722575-84886505 bp, + strand Genetic Position: Chr3, 37.7 cM, cytoband E3.3
• Alliance: Fbxw7^tm1Kin page

Vascular abnormalities in Fbxw7^tm1Kin/Fbxw7^tm1Kin embryos

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88517
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 15 kb genomic fragment containing exons 1 through 5, which encode the N-terminal and F-box domains of the protein, was replaced by a floxed neo cassette. mRNA was undetected by in situ hybridization of homozygous mutant embryos. (J:88517)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fbxw7^tm1Kin

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbxw7 Mutation: 84 strains or lines available

References

• Original: J:88517 Tsunematsu R, et al., Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem. 2004 Mar 5;279(10):9417-23
• All: 7 reference(s)