Fibrs1^C3H/He
QTL Variant Detail

Summary

• QTL variant: Fibrs1^C3H/He
• Name: fibrosarcoma susceptibility 1; C3H/He
• MGI ID: MGI:3036582
• QTL: Fibrs1 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: C3H/He

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:87283

Linkage analysis was performed on 267 animals from a 4-way cross involving (BALB/c x C57BL/6)F1 x (C3H/He x DBA/2)F1 to identify QTLs associated with susceptibility to fibrosarcomas. 90 polymorphic loci were analyzed resulting in the detection of 3 fibrosarcoma-associated QTLs.

Fibrs1 and Fibrs2 mapped to 11 cM (P=0.0117) and 92 cM (P=0.0186) on mouse Chromosome 4, respectively. Fibrs1 explains 34% of the phenotypic variance and Fibrs2 explains 27% of the phenotypic variance.

Fibrs3 mapped to 24 cM on mouse Chromosome 13 and explains 26% of the phenotypic variance.

References

• Original: J:87283 Xu S, et al., An EM algorithm for mapping binary disease loci: application to fibrosarcoma in a four-way cross mouse family. Genet Res. 2003 Oct;82(2):127-38
• All: 1 reference(s)