Elk4^tm1Rtr
Targeted Allele Detail

Summary

• Symbol: Elk4^tm1Rtr
• Name: ELK4, member of ETS oncogene family; targeted mutation 1, Richard Treisman
• MGI ID: MGI:3036598
• Synonyms: SAP-1^-
• Gene: Elk4 Location: Chr1:131935129-131954186 bp, + strand Genetic Position: Chr1, 57.24 cM, cytoband E3-G
• Alliance: Elk4^tm1Rtr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88515
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 1 and all of exons 2 and 3 were replaced with an IRES-lacZ-neo cassette. Transcript was undetected in the thymi of homozygous mutant mice by RNAse protection. lacZ expression was not reported. (J:88515)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elk4 Mutation: 17 strains or lines available

References

• Original: J:88515 Costello PS, et al., Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection. Nat Immunol. 2004 Mar;5(3):289-98
• All: 8 reference(s)